科学家研发出能用于组织粘附的双面胶带 -9778818威尼斯

可用于粘接湿组织和植入设备的双面干燥胶带，这一成果由美国麻省理工学院赵选贺（xuanhe zhao）研究组近日取得。10月30日，《自然》杂志在线发表了这一最新研究成果。

研究人员研发出一种替代的组织粘合剂，其形式为干式双面胶带（dst），由生物聚合物（明胶或壳聚糖）和接枝有n-氢琥珀酰亚胺酯的交联聚丙烯酸组成。这种dst的粘附机制取决于从组织表面去除界面水，从而导致与表面的快速临时交联。随后与组织表面上的胺基进行共价交联进一步改善了dst的粘附稳定性和强度。体外小鼠、体内大鼠和离体猪模型表明，dst可以在五秒钟内在各种湿动态组织和工程固体之间实现强力粘附。dst可用作组织粘合剂和密封剂，以及将可穿戴和可植入设备粘附到湿组织上。

据介绍，两个干燥的表面可以通过分子间的力（例如氢键、静电相互作用和范德华相互作用）在相互接触时立即粘附。但是，当涉及到湿润的表面（如人体组织）时，这种即时粘合力极具挑战性，因为水会将两个表面的分子分开，阻止了相互作用。尽管组织胶粘剂相对于缝合或缝合具有潜在的优势，但现有的液体或水凝胶组织胶粘剂仍存在一些局限性：粘合力弱、生物相容性低、与组织的机械匹配性差以及粘连形成缓慢。

附：英文原文

title: dry double-sided tape for adhesion of wet tissues and devices

author: hyunwoo yuk, claudia e. varela, christoph s. nabzdyk, xinyu mao, robert f. padera, ellen t. roche, xuanhe zhao

issue&volume: 2019-10-30

abstract: two dry surfaces can instantly adhere upon contact with each other through intermolecular forces such as hydrogen bonds, electrostatic interactions and van der waals interactions1,2. however, such instant adhesion is challenging when wet surfaces such as body tissues are involved, because water separates the molecules of the two surfaces, preventing interactions3,4. although tissue adhesives have potential advantages over suturing or stapling5,6, existing liquid or hydrogel tissue adhesives suffer from several limitations: weak bonding, low biological compatibility, poor mechanical match with tissues, and slow adhesion formation513. here we propose an alternative tissue adhesive in the form of a dry double-sided tape (dst) made from a combination of a biopolymer (gelatin or chitosan) and crosslinked poly(acrylic acid) grafted with n-hydrosuccinimide ester. the adhesion mechanism of this dst relies on the removal of interfacial water from the tissue surface, resulting in fast temporary crosslinking to the surface. subsequent covalent crosslinking with amine groups on the tissue surface further improves the adhesion stability and strength of the dst. in vitro mouse, in vivo rat and ex vivo porcine models show that the dst can achieve strong adhesion between diverse wet dynamic tissues and engineering solids within five seconds. the dst may be useful as a tissue adhesive and sealant, and in adhering wearable and implantable devices to wet tissues. a new strong, biocompatible and biodegradable double-sided tape can adhere to wet tissues and devices through a mechanism involving rapid water removal from the surface, swift hydrogen and electrostatic interactions, and covalent bonding.

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